منابع مشابه
Vesicle traffic in vitro
My first encounter with the Golgi complex was on a trip to interview prospective postdoctoral mentors. I dropped in on Jim Rothman, who had recently arrived at the Department of Biochemistry at Stanford to explore the inner workings of the secretory pathway. Three hours later, after a very intense dialog on the need to study the function of the Golgi biochemically, I was hooked. In 1980, the ce...
متن کاملVesicle traffic: Get your coat!
The budding of transport vesicles from the Golgi complex is initiated by activation of the small GTPase ARF; the discovery of enzymes that can convert soluble ARF-GDP to the active, membrane-associated form ARF-GTP will shed light on the mechanism and regulation of the formation of transport vesicles.
متن کاملVesicle tethering complexes in membrane traffic.
Despite the recent progress in the field of membrane traffic, the question of how the specificity of membrane fusion is achieved has yet to be resolved. It has become apparent that the SNARE proteins, although central to the process of fusion, are often not the first point of contact between a vesicle and its target. Instead, a poorly understood tethering process physically links the two before...
متن کاملPhysiopathologic dynamics of vesicle traffic in astrocytes.
The view of how astrocytes, a type of glial cells, contribute to the functioning of the central nervous system (CNS) has changed greatly in the last decade. Although glial cells outnumber neurons in the mammalian brain, it was considered for over a century that they played a subservient role to neurons. This view changed. Functions thought to be exclusively present in neurons, i.e. excitability...
متن کاملVitrification of human germinal vesicle oocytes; before or after in vitro maturation?
Background The utilization of immature oocytes derived from stimulated cycles could be of great importance, specially for urgent fertility preservation cases. The aim of the current study was to determine whether in-vitro maturation is more successful before or after the vitrification of these oocytes. MaterialsAndMethods The study was performed in a private IVF center. 318 germinal vesicle (GV...
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ژورنال
عنوان ژورنال: Cell
سال: 2004
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(03)00970-x